Altered Ex Vivo NLRP3 Inflammasome Activation Is Associated with 28-Day Mortality in Septic Patients

Altered Ex Vivo NLRP3 Inflammasome Activation Is Associated with 28-Day Mortality in Septic Patients

Sepsis is a life-threatening organ dysfunction caused by a dysregulated response to infection. In this context, the aberrant activation of the NLRP3 inflammasome has been documented mostly through the measurement of increased plasmatic concentrations of IL-1β and IL-18. At the cellular level, contra...

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Bibliographic Details
Main Authors: Rémy Coudereau, Guillaume Monneret, Anne-Claire Lukaszewicz, Bénédicte F. Py, Laurent Argaud, Martin Cour, Frank Bidar, Morgane Gossez, Fabienne Venet
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Viruses
Subjects:
sepsis
COVID-19
inflammation
NLRP3 inflammasome
ASC speck
caspase-1
Online Access:https://www.mdpi.com/1999-4915/15/12/2419

Internet

https://www.mdpi.com/1999-4915/15/12/2419

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