Inhibitory receptors of plasmacytoid dendritic cells as possible targets for checkpoint blockade in cancer

Inhibitory receptors of plasmacytoid dendritic cells as possible targets for checkpoint blockade in cancer

Plasmacytoid dendritic cells (pDCs) are the major producers of type I interferons (IFNs), which are essential to mount antiviral and antitumoral immune responses. To avoid exaggerated levels of type I IFNs, which pave the way to immune dysregulation and autoimmunity, pDC activation is strictly regul...

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Bibliographic Details
Main Authors: Laura Tiberio, Mattia Laffranchi, Giovanni Zucchi, Valentina Salvi, Tiziana Schioppa, Silvano Sozzani, Annalisa Del Prete, Daniela Bosisio
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
BDCA-2
ILT7
pDC exhaustion
C-type lectin receptor
TLR7
checkpoint inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1360291/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1360291/full

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