Enhancement of apixaban's solubility and dissolution rate by inclusion complex (β-cyclodextrin and hydroxypropyl β-cyclo¬dextrin) and computational calculation of their inclusion complexes

Enhancement of apixaban's solubility and dissolution rate by inclusion complex (β-cyclodextrin and hydroxypropyl β-cyclo¬dextrin) and computational calculation of their inclusion complexes

Background and Purpose: Apixaban (AP) is a factor X inhibitor, an orally active drug that inhibits blood coagulation for better prevention of venous thromboembolism. It has poor solubility, dissolution rate and low bioavailability. The aim of this study was to improve the aqueous solubility and dis...

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Bibliographic Details
Main Authors: Zainab N. Salman, Israa Al-Ani, Khaldun M. Al Azzam, Bashar JM. Majeed, Hassan H. Abdallah, El-Sayed Negim
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2023-08-01
Series:ADMET and DMPK
Subjects:
Apixaban
HPβCD
βCD
capsule
bioavailability
solubility
Online Access:https://pub.iapchem.org/ojs/index.php/admet/article/view/1885

Internet

https://pub.iapchem.org/ojs/index.php/admet/article/view/1885

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