Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells

Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells

Using two representative models of androgen-independent prostate cancer (PCa), PC3 and DU145, and their respective paclitaxel- and docetaxel-resistant derivatives, we explored the anti-tumor activity of targeting the ErbB receptors and AKT using small-molecule kinase inhibitors. These cells manifest...

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Bibliographic Details
Main Authors: Samusi Adediran, Linbo Wang, Mohammad Afnan Khan, Wei Guang, Xiaoxuan Fan, Hancai Dan, Jianfei Qi, Steven M. Jay, France Carrier, Arif Hussain
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
prostate cancer
drug resistance
cell signaling
Online Access:https://www.mdpi.com/2072-6694/14/19/4626

Internet

https://www.mdpi.com/2072-6694/14/19/4626

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