Detection of BRCA1/2 pathogenic variants in patients with breast and/or ovarian cancer and their families. Analysis of 3,458 cases from Lower Silesia (Poland) according to the diagnostic algorithm of the National Cancer Control Programme

Detection of BRCA1/2 pathogenic variants in patients with breast and/or ovarian cancer and their families. Analysis of 3,458 cases from Lower Silesia (Poland) according to the diagnostic algorithm of the National Cancer Control Programme

Breast and ovarian cancers are among the most common malignancies in the female population, with approximately 5–10% of cases being hereditary. BRCA1 and BRCA2 with other homologous recombination genes are the most tested genes in hereditary breast and ovarian cancer (HBOC) patients. As next-generat...

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Bibliographic Details
Main Authors: Anna Doraczynska-Kowalik, Dagmara Michalowska, Rafal Matkowski, Ewelina Czykalko, Dorota Blomka, Mariola Semeniuk, Mariola Abrahamowska, Gabriela Janus-Szymanska, Paulina Mlynarczykowska, Bartlomiej Szynglarewicz, Ireneusz Pawlak, Adam Maciejczyk, Izabela Laczmanska
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Genetics
Subjects:
HBOC
BRCA1/2
NGS
diagnostics
algorithm
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.941375/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.941375/full

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