Investigating the shared genetic architecture between breast and ovarian cancers

Investigating the shared genetic architecture between breast and ovarian cancers

Abstract High heritability and strong correlation have been observed in breast and ovarian cancers. However, their shared genetic architecture remained unclear. Linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics (ρ-HESS) were applied to estimate herita...

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Bibliographic Details
Main Authors: Xuezhong Shi, Anqi Bu, Yongli Yang, Yuping Wang, Chenyu Zhao, Jingwen Fan, Chaojun Yang, Xiaocan Jia
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2024-04-01
Series:Genetics and Molecular Biology
Subjects:
Genome-Wide Association Study
ovarian neoplasms
genetic pleiotropy
linkage disequilibrium
polymorphism
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572024000300801&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572024000300801&lng=en&tlng=en

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