Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain

Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain

The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from tarantula venom that inhibits human NaV1.7 activatio...

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Bibliographic Details
Main Authors: Phuong T Nguyen, Hai M Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
pain
sodium channels
peptide toxins
rosetta
protein design
Online Access:https://elifesciences.org/articles/81727

Internet

https://elifesciences.org/articles/81727

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