Coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic Ser/Thr kinase Pim-1.

Coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic Ser/Thr kinase Pim-1.

The serine/threonine kinase Pim-1 directs selected signaling events that promote cell growth and survival and is overexpressed in diverse human cancers. Pim-1 expression is tightly controlled through multiple mechanisms, including regulation of mRNA turnover. In several cultured cell models, mitogen...

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Bibliographic Details
Main Authors: Dig B Mahat, Sarah E Brennan-Laun, Elizabeth J Fialcowitz-White, Aparna Kishor, Christina R Ross, Tatyana Pozharskaya, J David Rawn, Perry J Blackshear, Bret A Hassel, Gerald M Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3297641?pdf=render

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http://europepmc.org/articles/PMC3297641?pdf=render

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