HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma

HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma

Voltage-dependent anion-selective channel protein 1 (VDAC1) is the most abundant protein in the mitochondrial outer membrane and plays a crucial role in the control of hepatocellular carcinoma (HCC) progress. Our previous research found that cytosolic molecular chaperone heat shock protein 90 (Hsp90...

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Bibliographic Details
Main Authors: Jinxin Zhang, Lixia Liu, Yan Li, Yaling Huang, Senbo Xiao, Zihao Deng, Zhenming Zheng, Jieyou Li, Manfeng Liang, Guantai Xie, Xiao Chen, Yaotang Deng, Wenchong Tan, Hairou Su, Guibing Wu, Chunqing Cai, Xuemei Chen, Fei Zou
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Voltage-dependent anion-selective channel protein 1
Heat shock protein 90 inhibitor
Oligomerization
Apoptosis
Hepatocellular carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558623000593

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http://www.sciencedirect.com/science/article/pii/S1476558623000593

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