Abnormal brain oxygen homeostasis in an animal model of liver disease

Abnormal brain oxygen homeostasis in an animal model of liver disease

Background & Aims: Increased plasma ammonia concentration and consequent disruption of brain energy metabolism could underpin the pathogenesis of hepatic encephalopathy (HE). Brain energy homeostasis relies on effective maintenance of brain oxygenation, and dysregulation impairs neuronal fun...

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Bibliographic Details
Main Authors: Anna Hadjihambi, Cristina Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Chris Donnelly, Christos Konstantinou, Nathan Davies, Abeba Habtesion, Alexander V. Gourine, Rajiv Jalan, Patrick S. Hosford
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:JHEP Reports
Subjects:
Oxygen
Ornithine phenylacetate
Chronic liver disease
Hyperammonaemia
Phenylephrine
hepatic encephalopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555922000817

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http://www.sciencedirect.com/science/article/pii/S2589555922000817

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