Identification of new inhibitors of the kinase acti­vity of CDK2 and CDK9 by molecular modeling and high-efficiency screening

Identification of new inhibitors of the kinase acti­vity of CDK2 and CDK9 by molecular modeling and high-efficiency screening

Kinases are important components of many signaling pathways in a cell, and therefore they are involved in the regulation of such diverse processes as trans­cription, cell cycle progression, apoptosis, cell differentiation, metabolism, and intercellular communication. Their increased activity often r...

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Bibliographic Details
Main Authors: G.V. Andrianov, I.G. Serebriiskii
Format: Article
Language:English
Published: Kazan Federal University 2021-12-01
Series:Учёные записки Казанского университета: Серия Естественные науки
Subjects:
virtual screening
structural alignment
energy minimization of ligand-target complex
protein kinase
cdk2
cdk9
Online Access:https://kpfu.ru/uz-eng-ns-2021-4-1.html

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https://kpfu.ru/uz-eng-ns-2021-4-1.html

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