In silico studies of piperazine derivatives as potent anti-proliferative agents against PC-3 prostate cancer cell lines

In silico studies of piperazine derivatives as potent anti-proliferative agents against PC-3 prostate cancer cell lines

Quantitative Structure Activity Relationship studies were carried out on arylpiperazine derivatives to investigate their anti-proliferate activity against prostate PC-3 cancer cell lines. The built model with statistical parameters; R2 = 0.8483, R2adj = 0.8078, Q2cv = 0.7122 and external validation...

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Bibliographic Details
Main Authors: Fabian A. Ikwu, Gideon A. Shallangwa, Paul A. Mamza, Adamu Uzairu
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Heliyon
Subjects:
Cancer research
Theoretical chemistry
Quantitative structure activity relationship
Molecular docking
Prostate cancer
Computational chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020301183

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http://www.sciencedirect.com/science/article/pii/S2405844020301183

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