Chemoproteomics Reveals USP5 (Ubiquitin Carboxyl-Terminal Hydrolase 5) as Promising Target of the Marine Polyketide Gracilioether A

Chemoproteomics Reveals USP5 (Ubiquitin Carboxyl-Terminal Hydrolase 5) as Promising Target of the Marine Polyketide Gracilioether A

Mass spectrometry-based chemical proteomic approaches using limited proteolysis have become a powerful tool for the identification and analysis of the interactions between a small molecule (SM) and its protein target(s). Gracilioether A (GeA) is a polyketide isolated from a marine sponge, for which...

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Bibliographic Details
Main Authors: Alessandra Capuano, Gilda D’Urso, Michela Aliberti, Dafne Ruggiero, Stefania Terracciano, Carmen Festa, Alessandra Tosco, Maria Giovanna Chini, Gianluigi Lauro, Giuseppe Bifulco, Agostino Casapullo
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Marine Drugs
Subjects:
proteomics
drug affinity target stability
targeted-limited proteolysis
multiple reaction monitoring
marine bioactive compound
molecular docking
Online Access:https://www.mdpi.com/1660-3397/22/1/41

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https://www.mdpi.com/1660-3397/22/1/41

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