Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis

Enhancement of glial-derived neurotrophic factor (GDNF) is an established therapeutic target for amyotrophic lateral sclerosis (ALS). Activation of group II metabotropic glutamate (mGlu) receptors with the orthosteric agonist, LY379268, enhanced GDNF levels in cultured spinal cord astrocytes from wi...

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Detalhes bibliográficos
Principais autores: Giuseppe Battaglia, Barbara Riozzi, Domenico Bucci, Luisa Di Menna, Gemma Molinaro, Simone Pallottino, Ferdinando Nicoletti, Valeria Bruno
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2015-02-01
coleção:Neurobiology of Disease
Assuntos:
Metabotropic glutamate receptor
Neurodegeneration
Neuroprotection
Amyotrophic lateral sclerosis
GDNF
GLT-1
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S096999611400357X

Internet

http://www.sciencedirect.com/science/article/pii/S096999611400357X

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