Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

Both BRCA1 and Beclin 1 (BECN1) are tumor suppressor genes, which are in close proximity on the human chromosome 17q21 breast cancer tumor susceptibility locus and are often concurrently deleted. However, their importance in sporadic human breast cancer is not known. To interrogate the effects of BE...

Full description

Bibliographic Details
Main Authors: Hao Tang, Salwa Sebti, Rossella Titone, Yunyun Zhou, Ciro Isidoro, Theodora S. Ross, Hanina Hibshoosh, Guanghua Xiao, Milton Packer, Yang Xie, Beth Levine
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:EBioMedicine
Subjects:
BECN1
BRCA1
Breast cancer
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415000316

Internet

http://www.sciencedirect.com/science/article/pii/S2352396415000316

Similar Items