Scallop hydrolysates/κ-carrageenan hydrogels improve the alleviating effect of curcumin on DSS-induced colitis
Scallop (Patinopecten yessoensis) male gonad hydrolysates/κ-carrageenan (SK) double cross-linking network hydrogels were constructed as curcumin (Cur) delivery vehicles with good gel mechanical property and homogeneous honeycomb microstructures. Compared with Cur + DSS group, weight loss and colon l...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624000021 |
| _version_ | 1797356124611018752 |
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| author | Jia-Nan Yan Yu-Qiao Wang Lin Li Zhu-Jun Zhang Ling-Yi Gao Bin Lai Ce Wang Li-Chao Zhang Hai-Tao Wu |
| author_facet | Jia-Nan Yan Yu-Qiao Wang Lin Li Zhu-Jun Zhang Ling-Yi Gao Bin Lai Ce Wang Li-Chao Zhang Hai-Tao Wu |
| author_sort | Jia-Nan Yan |
| collection | DOAJ |
| description | Scallop (Patinopecten yessoensis) male gonad hydrolysates/κ-carrageenan (SK) double cross-linking network hydrogels were constructed as curcumin (Cur) delivery vehicles with good gel mechanical property and homogeneous honeycomb microstructures. Compared with Cur + DSS group, weight loss and colon length in SK-Cur + DSS group increased about 1.04 and 1.06 folds, while the disease active index (DAI) scores decreased about 13 %. Moreover, SK-Cur showed superior effect on intestinal barrier improvement, oxidative stress modulation, and inflammatory expression regulation, reflected by 1.1 folds increment of epithelial tight junction proteins, 16 % and 27 % decline in MPO and iNOS levels, 20 % decline in NF-κB expression, 4 %, 7 %, 6 % decline in TNF-α, IL-1β, IL-6 expression in serum, and 9 %, 20 %, 7 % decline in TNF-α, IL-1β, IL-6 expression in colon tissue. Furthermore, SK-Cur enriched alpha diversity and restored taxonomic composition with increasing Bacteroides and Verrucomicrobia abundance accompanied by decreasing Firmicutes in DSS-induced UC mice, roughly to a normal gut flora state. |
| first_indexed | 2024-03-08T14:21:06Z |
| format | Article |
| id | doaj.art-61c400c9d2be421bb2c39b444fe4fa80 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T14:21:06Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-61c400c9d2be421bb2c39b444fe4fa802024-01-14T05:37:31ZengElsevierJournal of Functional Foods1756-46462024-01-01112106000Scallop hydrolysates/κ-carrageenan hydrogels improve the alleviating effect of curcumin on DSS-induced colitisJia-Nan Yan0Yu-Qiao Wang1Lin Li2Zhu-Jun Zhang3Ling-Yi Gao4Bin Lai5Ce Wang6Li-Chao Zhang7Hai-Tao Wu8School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; Institutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Dalian 116034, China; Corresponding author.Scallop (Patinopecten yessoensis) male gonad hydrolysates/κ-carrageenan (SK) double cross-linking network hydrogels were constructed as curcumin (Cur) delivery vehicles with good gel mechanical property and homogeneous honeycomb microstructures. Compared with Cur + DSS group, weight loss and colon length in SK-Cur + DSS group increased about 1.04 and 1.06 folds, while the disease active index (DAI) scores decreased about 13 %. Moreover, SK-Cur showed superior effect on intestinal barrier improvement, oxidative stress modulation, and inflammatory expression regulation, reflected by 1.1 folds increment of epithelial tight junction proteins, 16 % and 27 % decline in MPO and iNOS levels, 20 % decline in NF-κB expression, 4 %, 7 %, 6 % decline in TNF-α, IL-1β, IL-6 expression in serum, and 9 %, 20 %, 7 % decline in TNF-α, IL-1β, IL-6 expression in colon tissue. Furthermore, SK-Cur enriched alpha diversity and restored taxonomic composition with increasing Bacteroides and Verrucomicrobia abundance accompanied by decreasing Firmicutes in DSS-induced UC mice, roughly to a normal gut flora state.http://www.sciencedirect.com/science/article/pii/S1756464624000021Ulcerative colitisScallopκ-CarrageenanCurcuminInflammatory expressionGut flora |
| spellingShingle | Jia-Nan Yan Yu-Qiao Wang Lin Li Zhu-Jun Zhang Ling-Yi Gao Bin Lai Ce Wang Li-Chao Zhang Hai-Tao Wu Scallop hydrolysates/κ-carrageenan hydrogels improve the alleviating effect of curcumin on DSS-induced colitis Journal of Functional Foods Ulcerative colitis Scallop κ-Carrageenan Curcumin Inflammatory expression Gut flora |
| title | Scallop hydrolysates/κ-carrageenan hydrogels improve the alleviating effect of curcumin on DSS-induced colitis |
| title_full | Scallop hydrolysates/κ-carrageenan hydrogels improve the alleviating effect of curcumin on DSS-induced colitis |
| title_fullStr | Scallop hydrolysates/κ-carrageenan hydrogels improve the alleviating effect of curcumin on DSS-induced colitis |
| title_full_unstemmed | Scallop hydrolysates/κ-carrageenan hydrogels improve the alleviating effect of curcumin on DSS-induced colitis |
| title_short | Scallop hydrolysates/κ-carrageenan hydrogels improve the alleviating effect of curcumin on DSS-induced colitis |
| title_sort | scallop hydrolysates κ carrageenan hydrogels improve the alleviating effect of curcumin on dss induced colitis |
| topic | Ulcerative colitis Scallop κ-Carrageenan Curcumin Inflammatory expression Gut flora |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624000021 |
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