M2 Macrophage‐Derived sEV Regulate Pro‐Inflammatory CCR2+ Macrophage Subpopulations to Favor Post‐AMI Cardiac Repair

M2 Macrophage‐Derived sEV Regulate Pro‐Inflammatory CCR2+ Macrophage Subpopulations to Favor Post‐AMI Cardiac Repair

Abstract Tissue‐resident cardiac macrophage subsets mediate cardiac tissue inflammation and repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)‐expressing macrophages have phenotypical similarities to M1‐polarized macrophages, are pro‐inflammatory, and recruit CCR2+ circul...

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Bibliographic Details
Main Authors: Lan Li, Jiasong Cao, Sheng Li, Tianyi Cui, Jingyu Ni, Han Zhang, Yan Zhu, Jingyuan Mao, Xiumei Gao, Adam C. Midgley, Meifeng Zhu, Guanwei Fan
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
CC chemokine receptor 2
extracellular vesicles
ischemia‐reperfusion injury
macrophage metabolic reprogramming
macrophages
Online Access:https://doi.org/10.1002/advs.202202964

Internet

https://doi.org/10.1002/advs.202202964

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