Cysteinyl leukotriene-like metabolites are generated in retinal pigment epithelial cells through glutathionylation/reduction of an oxidatively truncated fragment of arachidonate

Cysteinyl leukotriene-like metabolites are generated in retinal pigment epithelial cells through glutathionylation/reduction of an oxidatively truncated fragment of arachidonate

γ-Hydroxyalkenals, 4-hydroxynonenal (HNE) and phospholipid esters of 4-hydroxy-8-oxooctenoic acid (HOOA-PL), are produced from the alkyl and carboxyl termini of arachidonyl phospholipids by radical-induced oxidative cleavage. Metabolism of HNE by Michael addition of glutathione (GSH) followed by red...

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Bibliographic Details
Main Authors: Mikhail Linetsky, Anshula Mondal, Si-Yang Liu, Abby M. Hite, Shravani Enduri, Yu-Shiuan Cheng, Beatriz Feijo, Graham Kang, Nana Arhin, Hong Zeng, Olivia R. Laniak, John Denker, Robert G. Salomon
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Results in Chemistry
Subjects:
Pseudo leukotrienes
Retinal Pigment Epithelial Cells
Free radical-induced lipid oxidation
Hypoxia-inducible factor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715623002345

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http://www.sciencedirect.com/science/article/pii/S2211715623002345

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