Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection

Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection

Hyperglycaemia at the time of myocardial infarction has an adverse effect on prognosis irrespective of a prior diagnosis of diabetes, suggesting glucose is the damaging factor. In ex vivo models of ischaemia, we demonstrated that deleterious effects of acutely elevated glucose are PKCα/β-dependent,...

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Bibliographic Details
Main Authors: Sean Brennan, Simona Esposito, Muhammad I. M. Abdelaziz, Christopher A. Martin, Samir Makwana, Mark W. Sims, Iain B. Squire, Parveen Sharma, Amy E. Chadwick, Richard D. Rainbow
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
glucose
cardiotoxicity
cardioprotection
hyperglycaemia
protein kinase C (PKC)
time-dependent
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.997013/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.997013/full

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