Microfluidic intestinal organoid-on-a-chip uncovers therapeutic targets by recapitulating oxygen dynamics of intestinal IR injury

Microfluidic intestinal organoid-on-a-chip uncovers therapeutic targets by recapitulating oxygen dynamics of intestinal IR injury

Increasing evidence demonstrates that mammals have different reactions to hypoxia with varied oxygen dynamic patterns. It takes ∼24 h for tri-gas incubator to achieve steady cell hypoxia, which fails to recapitulate ultrafast oxygen dynamics of intestinal ischemia/reperfusion (IR) injury. Inspired f...

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Bibliographic Details
Main Authors: Jinjian Huang, Ziyan Xu, Jiao Jiao, Zongan Li, Sicheng Li, Ye Liu, Ze Li, Guiwen Qu, Jie Wu, Yun Zhao, Kang Chen, Jieshou Li, Yichang Pan, Xiuwen Wu, Jianan Ren
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-12-01
Series:Bioactive Materials
Subjects:
Ionic barrier of ZIF-8
Microfluidics
Organoid-on-a-chip
Oxygen dynamics
Olfm4
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X23002062

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http://www.sciencedirect.com/science/article/pii/S2452199X23002062

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