Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes

Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons (MNs). Astrocytes display a toxic phenotype in ALS, which results in MN damage. Glutamate (Glu)-mediated excitotoxicity and group I metabotropic glutamate receptors (mG...

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Bibliographic Details
Main Authors: Carola Torazza, Francesca Provenzano, Elena Gallia, Maria Cerminara, Matilde Balbi, Tiziana Bonifacino, Sara Tessitore, Silvia Ravera, Cesare Usai, Ilaria Musante, Aldamaria Puliti, Ludo Van Den Bosch, Paymaan Jafar-nejad, Frank Rigo, Marco Milanese, Giambattista Bonanno
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
amyotrophic lateral sclerosis
mGlu5 receptor
adult mouse spinal cord astrocytes
<i>Grm5</i> genetic ablation
SOD1<sup>G93A</sup> mice
Online Access:https://www.mdpi.com/2073-4409/12/15/1952

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https://www.mdpi.com/2073-4409/12/15/1952

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