Collection of Data Variation Using a High-Throughput Image-Based Assay Platform Facilitates Data-Driven Understanding of TRPA1 Agonist Diversity

Collection of Data Variation Using a High-Throughput Image-Based Assay Platform Facilitates Data-Driven Understanding of TRPA1 Agonist Diversity

Because transient receptor potential ankyrin 1 (TRPA1) is involved in various physiological functions, TRPA1-targeting drugs have been energetically developed. Although TRPA1 is considered a multimodal receptor, the structural diversity of TRPA1 agonists is not fully elucidated. We hypothesized that...

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Bibliographic Details
Main Authors: Yuko Terada, Kenjiro Tanaka, Minami Matsuyama, Masaya Fujitani, Masatoshi Shibuya, Yoshihiko Yamamoto, Ryuji Kato, Keisuke Ito
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Applied Sciences
Subjects:
TRPA1 agonist
image-based assay
Ca<sup>2+</sup> imaging
chemical library
physicochemical descriptors
clustering
Online Access:https://www.mdpi.com/2076-3417/12/3/1622

Internet

https://www.mdpi.com/2076-3417/12/3/1622

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