Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex

Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex

The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear. Here, we show that Wnt7a and secreted frizzled-related protein 1 (Sfrp1), a soluble modulator...

Full description

Bibliographic Details
Main Authors: Nan Miao, Shan Bian, Trevor Lee, Taufif Mubarak, Shiying Huang, Zhihong Wen, Ghulam Hussain, Tao Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Wnt7a
Sfrp1
cerebral cortex
neural progenitors
antagonist
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00247/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00247/full

Similar Items