Amantadine variant – aryl conjugates that inhibit multiple M2 mutant – amantadine resistant influenza a viruses

Amantadine variant – aryl conjugates that inhibit multiple M2 mutant – amantadine resistant influenza a viruses

Influenza A viruses can cause a serious future threat due to frequent mutations. Amantadine and rimantadine drugs inhibit influenza A M2 wild-type (WT; bearing in the protein M2 proton channel serine at position-31) viruses by binding and blocking M2 WT channel-mediated proton current. The resistant...

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Bibliographic Details
Main Authors: Christina Tzitzoglaki, Anja Hoffmann, Andreea L. Turcu, Patrick Schmerer, Chunlong Ma, George Laros, Christos Liolios, Brea José, Jun Wang, Santiago Vázquez, Michaela Schmidtke, Antonios Kolocouris
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Amantadine - aryl conjugate
In vitro ​antiviral activity
CPE
Electrophysiology
Influenza A M2 protein
A30T
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417422000553

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http://www.sciencedirect.com/science/article/pii/S2772417422000553

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