Tumor cell cytoplasmic metallothionein expression associates with differential tumor immunogenicity and prognostic outcome in high-grade serous ovarian carcinoma

Tumor cell cytoplasmic metallothionein expression associates with differential tumor immunogenicity and prognostic outcome in high-grade serous ovarian carcinoma

BackgroundThe underlying mechanism of high T-cell presence as a favorable prognostic factor in high-grade serous ovarian carcinoma (HGSOC) is not yet understood. In addition to immune cells, various cofactors are essential for immune processes. One of those are metallothioneins (MTs), metal-binding...

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Bibliographic Details
Main Authors: Elena Mairinger, Michael Wessolly, Paul Buderath, Sabrina Borchert, Larissa Henrich, Pawel Mach, Julia Steinborn, Rainer Kimming, Bharat Jasani, Kurt Werner Schmid, Agnes Bankfalvi, Fabian Dominik Mairinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Oncology
Subjects:
high-grade serous ovarian carcinoma
metallothionein
overall survival
immune response
zinc signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1252700/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1252700/full

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