Weakly supervised learning analysis of Aβ plaque distribution in the whole rat brain

Weakly supervised learning analysis of Aβ plaque distribution in the whole rat brain

Alzheimer’s disease (AD) is a great challenge for the world and hardly to be cured, partly because of the lack of animal models that fully mimic pathological progress. Recently, a rat model exhibiting the most pathological symptoms of AD has been reported. However, high-resolution imaging and accura...

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Bibliographic Details
Main Authors: Zhiyi Chen, Weijie Zheng, Keliang Pang, Debin Xia, Lingxiao Guo, Xuejin Chen, Feng Wu, Hao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Neuroscience
Subjects:
Aβ plaque
rat brain
deep learning
light sheet microscopy
weakly supervised learning segmentation
quantitative analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1097019/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.1097019/full

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