Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy

Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy

ObjectiveMetabolites derived from N−3 and N−6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated mitochondrial dysfunction remains unknown. This study aimed to charac...

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Bibliographic Details
Main Authors: Deanna K. Sosnowski, K. Lockhart Jamieson, Ahmed M. Darwesh, Hao Zhang, Hedieh Keshavarz-Bahaghighat, Robert Valencia, Anissa Viveiros, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, John M. Seubert
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
dilated cardiomyopathy (DCM)
eicosanoids
mitochondria
soluble epoxide hydrolase (sEH)
CYP450
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.879209/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.879209/full

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