The Vaccinia Virus DNA Helicase Structure from Combined Single-Particle Cryo-Electron Microscopy and AlphaFold2 Prediction

The Vaccinia Virus DNA Helicase Structure from Combined Single-Particle Cryo-Electron Microscopy and AlphaFold2 Prediction

Poxviruses are large DNA viruses with a linear double-stranded DNA genome circularized at the extremities. The helicase-primase D5, composed of six identical 90 kDa subunits, is required for DNA replication. D5 consists of a primase fragment flexibly attached to the hexameric C-terminal polypeptide...

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Bibliographic Details
Main Authors: Stephanie Hutin, Wai Li Ling, Nicolas Tarbouriech, Guy Schoehn, Clemens Grimm, Utz Fischer, Wim P. Burmeister
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Viruses
Subjects:
DNA replication
helicase
Pfam domain
poxvirus
cryo-electron microscopy
structure prediction
Online Access:https://www.mdpi.com/1999-4915/14/10/2206

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https://www.mdpi.com/1999-4915/14/10/2206

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