Synthesis of antibacterial 1,3-diyne-linked peptoids from an Ugi-4CR/Glaser coupling approach

Synthesis of antibacterial 1,3-diyne-linked peptoids from an Ugi-4CR/Glaser coupling approach

A library of ten 1,3-diyne-linked peptoids has been synthesized through an Ugi four-component reaction (U-4CR) followed by a copper-catalysed alkyne homocoupling (Glaser reaction). The short and chemoselective reaction sequence allows generating diverse (pseudo) dimeric peptoids. A combinatorial ver...

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Bibliographic Details
Main Authors: Martin C. N. Brauer, Ricardo A. W. Neves Filho, Bernhard Westermann, Ramona Heinke, Ludger A. Wessjohann
Format: Article
Language:English
Published: Beilstein-Institut 2015-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
antibacterial
combinatorial
diynes
homodimerization
multicomponent reactions
peptoids
Ugi reaction
Online Access:https://doi.org/10.3762/bjoc.11.4

Internet

https://doi.org/10.3762/bjoc.11.4

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