Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes

Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes

Abstract As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits downstream effectors for promoting insulin/IGF signals. However, the underlying molecular basis for this rema...

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Bibliographic Details
Main Authors: Xiu Kui Gao, Xi Sheng Rao, Xiao Xia Cong, Zu Kang Sheng, Yu Ting Sun, Shui Bo Xu, Jian Feng Wang, Yong Heng Liang, Lin Rong Lu, Hongwei Ouyang, Huiqing Ge, Jian-sheng Guo, Hang-jun Wu, Qi Ming Sun, Hao-bo Wu, Zhang Bao, Li Ling Zheng, Yi Ting Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00426-x

Internet

https://doi.org/10.1038/s41421-022-00426-x

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