Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1

Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1

Abstract Background Aberrant epigenetic and transcriptional events that drive cancer progression could be precisely targeted. We aimed to uncover the epigenetic roles of RBBP7 on breast cancer (BCa) stemness and metastasis. Methods The bioinformatic analysis was used to assess the clinical significa...

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Bibliographic Details
Main Authors: Yuanyin Xi, Ruoding Wang, Man Qu, Qinwen Pan, Minghao Wang, Xiang Ai, Zihan Sun, Chao Zhang, Peng Tang, Jun Jiang, Ying Hu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
RBBP7
Super-enhancer
Stemness
Metastasis
LSD1
Online Access:https://doi.org/10.1186/s12967-025-06270-3

Internet

https://doi.org/10.1186/s12967-025-06270-3

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