Oncogenic KRAS-Induced Protein Signature in the Tumor Secretome Identifies Laminin-C2 and Pentraxin-3 as Useful Biomarkers for the Early Diagnosis of Pancreatic Cancer

Oncogenic KRAS-Induced Protein Signature in the Tumor Secretome Identifies Laminin-C2 and Pentraxin-3 as Useful Biomarkers for the Early Diagnosis of Pancreatic Cancer

<i>KRAS</i> mutations characterize pancreatic cell transformation from the earliest stages of carcinogenesis, and are present in >95% of pancreatic ductal adenocarcinoma (PDAC) cases. In search of novel biomarkers for the early diagnosis of PDAC, we identified the proteins secreted by...

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Bibliographic Details
Main Authors: Mohammad Azhar Kamal, Imran Siddiqui, Cristina Belgiovine, Marialuisa Barbagallo, Valentina Paleari, Daniela Pistillo, Chiara Chiabrando, Silvia Schiarea, Barbara Bottazzi, Roberto Leone, Roberta Avigni, Roberta Migliore, Paola Spaggiari, Francesca Gavazzi, Giovanni Capretti, Federica Marchesi, Alberto Mantovani, Alessandro Zerbi, Paola Allavena
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
early diagnosis
biomarker
LAMC2
PTX3
proteomics
Online Access:https://www.mdpi.com/2072-6694/14/11/2653

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https://www.mdpi.com/2072-6694/14/11/2653

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