An Investigation of Structure–Activity Relationships and Cell Death Mechanisms of the Marine Alkaloids Discorhabdins in Merkel Cell Carcinoma Cells

A library of naturally occurring and semi-synthetic discorhabdins was assessed for their effects on Merkel cell carcinoma (MCC) cell viability. The set included five new natural products and semi-synthetic compounds whose structures were elucidated with NMR, HRMS, and ECD techniques. Several discorh...

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Bibliographic Details
Main Authors: Maria Orfanoudaki, Emily A. Smith, Natasha T. Hill, Khalid A. Garman, Isaac Brownell, Brent R. Copp, Tanja Grkovic, Curtis J. Henrich
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Marine Drugs
Subjects:
Online Access:https://www.mdpi.com/1660-3397/21/9/474