ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance

ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance

The ATP-binding cassette transporters (ABC transporters) have been intensely studied over the past 50 years for their involvement in the multidrug resistance (MDR) phenotype, especially in cancer. They are frequently overexpressed in both naive and post-treatment tumors, and hinder effective chemoth...

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Bibliographic Details
Main Authors: Wanjiru Muriithi, Lucy Wanjiku Macharia, Carlos Pilotto Heming, Juliana Lima Echevarria, Atunga Nyachieo, Paulo Niemeyer Filho, Vivaldo Moura Neto
Format: Article
Language:English
Published: China Anti-Cancer Association 2020-05-01
Series:Cancer Biology & Medicine
Subjects:
abc transporters
cancer aggressiveness
hallmarks of cancer
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1608

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/1608

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