Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration

Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration

Abstract Background Inflammasome activation and the subsequent release of pro-inflammatory cytokines including Interleukin 1β (IL-1β) have been widely reported to contribute to the progression of retinal degenerations, including age-related macular degeneration (AMD), the leading cause of blindness...

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Bibliographic Details
Main Authors: Rakshanya Sekar, Yvette Wooff, Adrian V. Cioanca, Melan Kurera, Chinh Ngo, Si Ming Man, Riccardo Natoli
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Neuroinflammation
Subjects:
Gasdermin D
Age-related macular degeneration (AMD)
Retinal degenerations
Neuroinflammation
Inflammasome
IL-1β
Online Access:https://doi.org/10.1186/s12974-023-02927-2

Internet

https://doi.org/10.1186/s12974-023-02927-2

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