The gephyrin scaffold modulates cortical layer 2/3 pyramidal neuron responsiveness to single whisker stimulation

The gephyrin scaffold modulates cortical layer 2/3 pyramidal neuron responsiveness to single whisker stimulation

Abstract Gephyrin is the main scaffolding protein at inhibitory postsynaptic sites, and its clusters are the signaling hubs where several molecular pathways converge. Post-translational modifications (PTMs) of gephyrin alter GABAA receptor clustering at the synapse, but it is unclear how this affect...

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Bibliographic Details
Main Authors: Yuan-Chen Tsai, Mohammad Hleihil, Kanako Otomo, Andrin Abegg, Anna Cavaccini, Patrizia Panzanelli, Teresa Cramer, Kim David Ferrari, Matthew J. P. Barrett, Giovanna Bosshard, Theofanis Karayannis, Bruno Weber, Shiva K. Tyagarajan, Jillian L. Stobart
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
GABAA receptors
Gephyrin
Barrel cortex
Electrophysiology
Two-photon calcium imaging
Online Access:https://doi.org/10.1038/s41598-024-54720-7

Internet

https://doi.org/10.1038/s41598-024-54720-7

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