RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages.

RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages.

Nuclear hormone receptors have important roles in the regulation of metabolic and inflammatory pathways. The retinoid-related orphan receptor alpha (Rorα)-deficient staggerer (sg/sg) mice display several phenotypes indicative of aberrant lipid metabolism, including dyslipidemia, and increased suscep...

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Bibliographic Details
Main Authors: Zewen Kelvin Tuong, Patrick Lau, Ximing Du, Nicholas D Condon, Joel M Goode, Tae Gyu Oh, Jeremy C Yeo, George E O Muscat, Jennifer L Stow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4727927?pdf=render

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http://europepmc.org/articles/PMC4727927?pdf=render

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