Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response.

Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response.

Dopamine (DA) neurons of the midbrain are at risk to become affected by mitochondrial damage over time and mitochondrial defects have been frequently reported in Parkinson's disease (PD) patients. However, the causal contribution of adult-onset mitochondrial dysfunction to PD remains uncertain....

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Bibliographic Details
Main Authors: Roberta Filograna, Seungmin Lee, Katarína Tiklová, Mara Mennuni, Viktor Jonsson, Markus Ringnér, Linda Gillberg, Elena Sopova, Oleg Shupliakov, Camilla Koolmeister, Lars Olson, Thomas Perlmann, Nils-Göran Larsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-09-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009822

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https://doi.org/10.1371/journal.pgen.1009822

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