Engineering advanced logic and distributed computing in human CAR immune cells

Most CAR designs lack control and computation features, limiting the sophistication of the engineered immune response. Here the authors leverage a split CAR design for engineering coordinated immune responses.

Bibliographic Details
Main Authors: Jang Hwan Cho, Atsushi Okuma, Katri Sofjan, Seunghee Lee, James J. Collins, Wilson W. Wong
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21078-7