Ligand Evolution in the Photoactivatable Platinum(IV) Anticancer Prodrugs

Ligand Evolution in the Photoactivatable Platinum(IV) Anticancer Prodrugs

Photoactivatable Pt(IV) anticancer prodrugs with the structure of [PtIV(N1)(N2)(L1)(L2)(A1)(A2)], where N1 and N2 are non-leaving nitrogen donor ligands, L1 and L2 are leaving ligands, and A1 and A2 are axial ligands, have attracted increasing attention due to their promising photo-cytotoxicity even...

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Bibliographic Details
Main Authors: Jingjing Huang, Weize Ding, Xingfan Zhu, Bingbing Li, Fangang Zeng, Kui Wu, Xiaoqin Wu, Fuyi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Chemistry
Subjects:
photoactivatable
platinum(IV) prodrug
anticancer
ligand
structure–activity relationship
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.876410/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.876410/full

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