Cyclophosphamide enfeebles myocardial isometric contraction force via RIP1/RIP3/MLKL/TRPM7-mediated necroptosis

Cyclophosphamide enfeebles myocardial isometric contraction force via RIP1/RIP3/MLKL/TRPM7-mediated necroptosis

This study explores the negative impact of cyclophosphamide (CP) on cardiac contractility by specifically examining its effect on the active and passive tension of the cardiac muscle in-vitro and revealing the mechanism through which CP induces myocardial insult in-vivo. In young male Sprague-Dawley...

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Bibliographic Details
Main Authors: Yasmin S. Abulfadl, Yousef Abo El Ela, Abdallah M. Al Khaiyat, Khalil I. Elkhodary, Mohamed Badran
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Isometric forces
Contractility
Cyclophosphamide
Cardiotoxicity
Necroptosis
TRPM7
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223006091

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223006091

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