A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes

A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes

To circumvent the limitations of available preclinical models for the study of type 1 diabetes (T1D), we developed a new humanized model, the YES-RIP-hB7.1 mouse. This mouse is deficient of murine major histocompatibility complex class I and class II, the murine insulin genes, and expresses as trans...

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Bibliographic Details
Main Authors: Sandrine Luce, Sophie Guinoiseau, Alexis Gadault, Franck Letourneur, Patrick Nitschke, Marc Bras, Michel Vidaud, Pierre Charneau, Etienne Larger, Maikel L. Colli, Decio L. Eizirik, François Lemonnier, Christian Boitard
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
type 1 diabetes (T1D)
humanized mouse
HLA-DQ8
epitopes
preproinsulin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.748679/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.748679/full

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