CMTR1-Catalyzed 2′-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2α Expression Independent of RIG-I Signaling

CMTR1-Catalyzed 2′-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2α Expression Independent of RIG-I Signaling

Summary: Eukaryotic mRNAs are 5′ end capped with a 7-methylguanosine, which is important for processing and translation of mRNAs. Cap methyltransferase 1 (CMTR1) catalyzes 2′-O-ribose methylation of the first transcribed nucleotide (N1 2′-O-Me) to mask mRNAs from innate immune surveillance by retino...

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Bibliographic Details
Main Authors: Yen-Lurk Lee, Fan-Che Kung, Chia-Hsuan Lin, Yi-Shuian Huang
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
2′-O-ribose methylation
CaMK2
cap1 modification
CMTR
dendrite development
innate immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312584

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http://www.sciencedirect.com/science/article/pii/S2211124720312584

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