The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress

The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress

Abstract The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid receptor, whose exact role in anxiety remains unknown. The present study was conducted to explore the possible mechanisms by which GPR55 regulates anxiety and to evaluate the effectiveness of O-1602 in the treatment of anxiety...

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Bibliographic Details
Main Authors: Qi-xin Shi, Liu-kun Yang, Wen-long Shi, Lu Wang, Shi-meng Zhou, Shao-yu Guan, Ming-gao Zhao, Qi Yang
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Molecular Brain
Subjects:
GPR55
O-1602
Medial orbital cortex
Stress
Anxiety
Online Access:http://link.springer.com/article/10.1186/s13041-017-0318-7

Internet

http://link.springer.com/article/10.1186/s13041-017-0318-7

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