Mycalamide A Shows Cytotoxic Properties and Prevents EGF-Induced Neoplastic Transformation through Inhibition of Nuclear Factors

Mycalamide A Shows Cytotoxic Properties and Prevents EGF-Induced Neoplastic Transformation through Inhibition of Nuclear Factors

Mycalamide A, a marine natural compound previously isolated from sponges, is known as a protein synthesis inhibitor with potent antitumor activity. However, the ability of this compound to prevent malignant transformation of cells has never been examined before. Here, for the first time, we report t...

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Bibliographic Details
Main Authors: Friedemann Honecker, Valentin A. Stonik, Carsten Bokemeyer, Larisa K. Shubina, Sergey A. Dyshlovoy, Anatoly I. Kalinovsky, Sergey N. Fedorov
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:Marine Drugs
Subjects:
mycalamide A
<em>Polysincraton</em> sp.
cancer preventive activity
apoptosis
AP-1
NF-κB
p53
Online Access:http://www.mdpi.com/1660-3397/10/6/1212

Internet

http://www.mdpi.com/1660-3397/10/6/1212

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