RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development

RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development

Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors. Mutations in the scaffolding domain of Ripk1 gene have been identified in humans with...

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Bibliographic Details
Main Authors: Thomas Hägglöf, Raksha Parthasarathy, Nathaniel Liendo, Elizabeth A. Dudley, Elizabeth A. Leadbetter
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
RIPK1
caspase 8
RIPK3
iNKT cell development
NK1.1+ cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1103591/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1103591/full

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