Antioxidant Efficacy of Olive By-Product Extracts in Human Colon HCT8 Cells
The production of olive oil is accompanied by the generation of a huge amount of waste and by-products including olive leaves, pomace, and wastewater. The latter represents a relevant environmental issue because they contain certain phytotoxic compounds that may need specific treatments before the e...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/10/1/11 |
| _version_ | 1827699478633644032 |
|---|---|
| author | Mariangela Centrone Mariagrazia D’Agostino Graziana Difonzo Alessandra De Bruno Annarita Di Mise Marianna Ranieri Cinzia Montemurro Giovanna Valenti Marco Poiana Francesco Caponio Grazia Tamma |
| author_facet | Mariangela Centrone Mariagrazia D’Agostino Graziana Difonzo Alessandra De Bruno Annarita Di Mise Marianna Ranieri Cinzia Montemurro Giovanna Valenti Marco Poiana Francesco Caponio Grazia Tamma |
| author_sort | Mariangela Centrone |
| collection | DOAJ |
| description | The production of olive oil is accompanied by the generation of a huge amount of waste and by-products including olive leaves, pomace, and wastewater. The latter represents a relevant environmental issue because they contain certain phytotoxic compounds that may need specific treatments before the expensive disposal. Therefore, reducing waste biomass and valorizing by-products would make olive oil production more sustainable. Here, we explore the biological actions of extracts deriving from olive by-products including olive pomace (OP), olive wastewater (OWW), and olive leaf (OLs) in human colorectal carcinoma HCT8 cells. Interestingly, with the same phenolic concentration, the extract obtained from the OWW showed higher antioxidant ability compared with the extracts derived from OP and OLs. These biological effects may be related to the differential phenolic composition of the extracts, as OWW extract contains the highest amount of hydroxytyrosol and tyrosol that are potent antioxidant compounds. Furthermore, OP extract that contains a higher level of vanillic acid than the other extracts displayed a cytotoxic action at the highest concentration. Together these findings revealed that phenols in the by-product extracts may interfere with signaling molecules that cross-link several intracellular pathways, raising the possibility to use them for beneficial health effects. |
| first_indexed | 2024-03-10T13:51:05Z |
| format | Article |
| id | doaj.art-62190e079b624906a2075855f518dd80 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T13:51:05Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-62190e079b624906a2075855f518dd802023-11-21T02:08:12ZengMDPI AGFoods2304-81582020-12-011011110.3390/foods10010011Antioxidant Efficacy of Olive By-Product Extracts in Human Colon HCT8 CellsMariangela Centrone0Mariagrazia D’Agostino1Graziana Difonzo2Alessandra De Bruno3Annarita Di Mise4Marianna Ranieri5Cinzia Montemurro6Giovanna Valenti7Marco Poiana8Francesco Caponio9Grazia Tamma10Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, ItalyDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 70125 Bari, ItalyDepartment of AGRARIA, University Mediterranea of Reggio Calabria, Vito, 89124 Reggio Calabria, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, ItalyDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 70125 Bari, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, ItalyDepartment of AGRARIA, University Mediterranea of Reggio Calabria, Vito, 89124 Reggio Calabria, ItalyDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 70125 Bari, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, ItalyThe production of olive oil is accompanied by the generation of a huge amount of waste and by-products including olive leaves, pomace, and wastewater. The latter represents a relevant environmental issue because they contain certain phytotoxic compounds that may need specific treatments before the expensive disposal. Therefore, reducing waste biomass and valorizing by-products would make olive oil production more sustainable. Here, we explore the biological actions of extracts deriving from olive by-products including olive pomace (OP), olive wastewater (OWW), and olive leaf (OLs) in human colorectal carcinoma HCT8 cells. Interestingly, with the same phenolic concentration, the extract obtained from the OWW showed higher antioxidant ability compared with the extracts derived from OP and OLs. These biological effects may be related to the differential phenolic composition of the extracts, as OWW extract contains the highest amount of hydroxytyrosol and tyrosol that are potent antioxidant compounds. Furthermore, OP extract that contains a higher level of vanillic acid than the other extracts displayed a cytotoxic action at the highest concentration. Together these findings revealed that phenols in the by-product extracts may interfere with signaling molecules that cross-link several intracellular pathways, raising the possibility to use them for beneficial health effects.https://www.mdpi.com/2304-8158/10/1/11olive by-productreactive oxygen species (ROS)olive leafpomaceolive wastewater |
| spellingShingle | Mariangela Centrone Mariagrazia D’Agostino Graziana Difonzo Alessandra De Bruno Annarita Di Mise Marianna Ranieri Cinzia Montemurro Giovanna Valenti Marco Poiana Francesco Caponio Grazia Tamma Antioxidant Efficacy of Olive By-Product Extracts in Human Colon HCT8 Cells Foods olive by-product reactive oxygen species (ROS) olive leaf pomace olive wastewater |
| title | Antioxidant Efficacy of Olive By-Product Extracts in Human Colon HCT8 Cells |
| title_full | Antioxidant Efficacy of Olive By-Product Extracts in Human Colon HCT8 Cells |
| title_fullStr | Antioxidant Efficacy of Olive By-Product Extracts in Human Colon HCT8 Cells |
| title_full_unstemmed | Antioxidant Efficacy of Olive By-Product Extracts in Human Colon HCT8 Cells |
| title_short | Antioxidant Efficacy of Olive By-Product Extracts in Human Colon HCT8 Cells |
| title_sort | antioxidant efficacy of olive by product extracts in human colon hct8 cells |
| topic | olive by-product reactive oxygen species (ROS) olive leaf pomace olive wastewater |
| url | https://www.mdpi.com/2304-8158/10/1/11 |
| work_keys_str_mv | AT mariangelacentrone antioxidantefficacyofolivebyproductextractsinhumancolonhct8cells AT mariagraziadagostino antioxidantefficacyofolivebyproductextractsinhumancolonhct8cells AT grazianadifonzo antioxidantefficacyofolivebyproductextractsinhumancolonhct8cells AT alessandradebruno antioxidantefficacyofolivebyproductextractsinhumancolonhct8cells AT annaritadimise antioxidantefficacyofolivebyproductextractsinhumancolonhct8cells AT mariannaranieri antioxidantefficacyofolivebyproductextractsinhumancolonhct8cells AT cinziamontemurro antioxidantefficacyofolivebyproductextractsinhumancolonhct8cells AT giovannavalenti antioxidantefficacyofolivebyproductextractsinhumancolonhct8cells AT marcopoiana antioxidantefficacyofolivebyproductextractsinhumancolonhct8cells AT francescocaponio antioxidantefficacyofolivebyproductextractsinhumancolonhct8cells AT graziatamma antioxidantefficacyofolivebyproductextractsinhumancolonhct8cells |