Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial

Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial

Background: Non-alcoholic liver steatosis (NAS) results from an imbalance between hepatic lipid storage, disposal, and partitioning. A multifactorial diet high in fiber, monounsaturated fatty acids (MUFAs), n-6 and n-3 polyunsaturated fatty acids (PUFAs), polyphenols, and vitamins D, E, and C reduce...

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Bibliographic Details
Main Authors: Giuseppina Costabile, Giuseppe Della Pepa, Dominic Salamone, Delia Luongo, Daniele Naviglio, Valentina Brancato, Carlo Cavaliere, Marco Salvatore, Paola Cipriano, Marilena Vitale, Alessandra Corrado, Angela Albarosa Rivellese, Giovanni Annuzzi, Lutgarda Bozzetto
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Nutrients
Subjects:
fatty liver
de novo lipogenesis
SCD1
β-hydroxybutyrate
polyphenols
MUFA
Online Access:https://www.mdpi.com/2072-6643/14/10/2178

Internet

https://www.mdpi.com/2072-6643/14/10/2178

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