TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint

Summary: Biochemical studies have indicated that p31comet and TRIP13 are critical for inactivating MAD2. To address unequivocally whether p31comet and TRIP13 are required for mitotic exit at the cellular level, their genes were ablated either individually or together in human cells. Neither p31comet...

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Bibliographic Details
Main Authors: Hoi Tang Ma, Randy Yat Choi Poon
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716000048