Type-I interferon pathway and DNA damage accumulation in peripheral blood of patients with psoriatic arthritis

Type-I interferon pathway and DNA damage accumulation in peripheral blood of patients with psoriatic arthritis

ObjectivesThe abnormal DNA damage response is associated with upregulation of the type-1 interferon (IFN-I) pathway in certain rheumatic diseases. We investigated whether such aberrant mechanisms operate in psoriatic arthritis (PsA).MethodsDNA damage levels were measured by alkaline comet assay in p...

Full description

Bibliographic Details
Main Authors: George E. Fragoulis, Panagiotis A. Ntouros, Adrianos Nezos, Nikolaos I. Vlachogiannis, Iain B. McInnes, Maria G. Tektonidou, Charalampos Skarlis, Vassilis L. Souliotis, Clio P. Mavragani, Petros P. Sfikakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
psoriatic arthritis
type-I Interferon
DNA damage
PBMC (peripheral blood mononuclear cells)
IL-6
IL-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1274060/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1274060/full

Similar Items